Risperidone-induced retrograde ejaculation.

TO THE EDITOR: Schizophrenic patients treated with antipsychotic drugs may suffer from a variety of sexually disabling side effects that can affect all domains of sexual activity. The most common such adverse effects in men are erectile dysfunction and retrograde ejaculation (1). Retrograde ejaculation has been mostly reported in association with typical antipsychotics, especially thioridazine (1); among the atypical antipsychotics, to our knowledge, only clozapine has been reported to cause retrograde ejaculation (2). We describe a schizophrenic patient with risperidone-induced ejaculatory failure that was compatible with retrograde ejaculation, both clinically and in the laboratory.